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In the cytoplasm, a “destruction complex” comprising adenomatous polyposis coli (APC), AXIN, casein kinase 1 (CK1) and glycogen synthase kinase 3 protein (GSK3 protein) captures β-catenin by phosphorylating CK1 and GSK3, thus activating the process of β-catenin degradation

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Pre-blends are less common for this stack than for cag/reta - separate vials are the standard