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The herbal extract Fucodian (from Hakim Shieu capsules) has been shown to reduce inflammatory markers and delay renal function decline via the AMPK–ULK1 signaling pathway ( Key TCM formulations such as Bombax ceiba ethanol extract and mangiferin help suppress ROS production and oxidative stress by inhibiting NOX4, and Nepeta angustifolia has been shown to inhibit peroxidase-induced apoptosis by modulating mitochondrial potential ( Further treatments targeting TGF-β/Smad and NLRP3 inflammasome include Dioscorea zingiberensis phenolic extract, which modulates P2X7 receptor expression and improves insulin resistance and fibrosis ( Several TCM compounds, including Epigallocatechin-3-gallate, Schisandra chinensis extract, and Panax notoginseng, help preserve podocyte integrity by inhibiting epithelial–mesenchymal transition (EMT) and modulating HIF1-α/VEGF pathways