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Brief pulses of high-level fluid shear stress enhance metastatic potential and rapidly alter the metabolism of cancer cells: Cell Reports

Computational systems biology

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This demonstrates that the SIN3B complex prefers deacetylating H3K27 over H3K9 and that H3K27 deacetylation depends on the SIN3B HDAC holo-complex assembly and specifically on the PHD finger 1 of PHF12 within the substrate receptor of SIN3B as shown in our structure

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