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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

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Clinical evaluation considerations: Baseline laboratory assessment (CBC, CMP, TSH, lipid panel) Targeted endocrine evaluation based on clinical presentation Nutritional status markers (vitamin D, vitamin B12, iron studies) Body composition analysis through DEXA scanning or bioelectrical impedance Referral to endocrinology for persistent unexplained difficulty gaining weight despite appropriate interventions Consultation with a registered dietitian (RD/RDN), preferably Board-Certified in Sports Dietetics Patients should seek medical evaluation if experiencing unintentional weight loss, heat intolerance, palpitations, excessive fatigue, night sweats, tremor, polyuria/polydipsia, disordered eating behaviors, menstrual irregularities, or other symptoms suggesting metabolic dysfunction