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All of these fibers function together to surround and orient the nuclear axis in line with the direction of fibroblast migration [60,61]
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In muscle tear models, the combination addresses both the inflammatory response and the structural repair phase simultaneously — with BPC-157 modulating pro-inflammatory cytokines (TNF-α, IL-6) and oxidative stress markers, and TB-500 recruiting progenitor cells and mesenchymal cells to the post-injury site while BPC-157 drives their subsequent differentiation and organisation
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