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Moreover, the aldo-keto reductase1 (AKR1) family of aldo-keto reductases can detoxify lipid-derived electrophiles [39]

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MPS I (Hurler-Scheie, stored dermatan sulfate, heparan sulfate) using targeted enzyme replacement therapy with alpha-L- iduronidase (e.g., laronidase (Aldurazyme marketed by Genzyme/Biomarin)