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Peroxynitrite generated in this manner is believed to be a potent mediator of oxidative stress in RBC (Minetti et al., 2008

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64 In a systemic review of 23 randomized controlled trials (RCTs), Cummings and White concluded that any effect derived from TPI is likely derived from the needle itself, rather than any specific substance injected, as there was no difference in therapeutic benefit of “wet” needling versus “dry” needling