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There are also strategies to enhance EPR in desmoplastic tumors, for examples, by disrupting dense stroma through ECM degradation (e.g., collagen or hyaluronan inhibitors), remodeling the TME via TGF-β inhibition, modulating vasculature by inhibiting VEGF signaling, and applying physical stimuli like mild hyperthermia or ultrasound to improve NPs penetration and distribution 353–354

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