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In bladder cancer, following FGFR3 mutation-driven SSP activation, increased serine synthesis activates the PI3K/Akt pathway in macrophages, inducing the formation of immunosuppressive macrophages and constructing an “immune-desert” microenvironment to facilitate immune escape ( 4.3.2.3 Epigenetic dysregulation subtype Hepatocellular carcinoma and breast cancer are typical examples of the epigenetic dysregulation subtype

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