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Even molecularly targeted agents face similar challenges—trastuzumab, while precisely binding HER2-positive breast cancer cells, can induce cardiac dysfunction due to baseline HER2 expression in cardiomyocytes, leading to premature treatment cessation in some patients [41, 42]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 267.Briggs Boedtkjer D, Rumessen J, Baandrup U, Skov Mikkelsen M, Telinius N, Pilegaard H, Aalkjaer C, Hjortdal V
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