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That breadth makes it the stronger candidate for questions involving: Insulin resistance and glucose uptake in skeletal muscle AMPK-dependent energy sensing under caloric restriction or exercise mimicry Mitochondrial stress responses and their systemic effects Age-related metabolic decline , given that circulating MOTS-c levels fall with age in humans For researchers already working with mitochondria-focused compounds, pairing MOTS-c with SS-31 (Elamipretide), a cardiolipin-targeting peptide, can help isolate whether an observed effect is driven by membrane integrity or by retrograde signaling