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Antioxidant Strategies for Age-Related Oxidative Damage in Dogs

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The activated NLRP3 inflammasome not only maintains myocardial interstitial inflammatory infiltration, but its induced proinflammatory factors, such as interleukin (IL)-18 and IL-1β, also activate profibrotic growth factors and promote the deposition of collagen and development of a profibrotic population of fibroblasts (46)

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