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Given the evidence on the endogenous antioxidant system, it is no surprise that research is turning its attention towards mitochondria-targeted exogenous antioxidants, which may hold promise as a therapeutic intervention for mitigating oxidative stress where excessive ROS exposure may be experienced, such as during prolonged endurance training

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In wildtype mice, optogenetic inhibition of GABAergic interneurons in the medial prefrontal cortex (mPFC) leads to cognitive deficits (29)