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For example, arginine methylation of cytokine receptor γ-chain regulates the lineage commitment of T cells ( GATA Binding Protein 3 ( GATA3 ) and IL4 loci whereas Th1 cells had increased 5hmC at IFNG and T-Box Transcription Factor 21 ( TBX21 ) loci ( SAM plays reciprocal roles in regulating T cell activation and effector function Hot et al

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Typical daily range: 150–600 mcg once daily — 150 mcg/day to start, titrating gradually to 600 mcg/day over 8 weeks

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