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Finally, we discuss the analytical challenges in characterizing SSG and the thiol PTM landscape, future directions for understanding of the role of SSG in redox signaling and regulation and its interplay with other PTMs, and the potential role of computational approaches to accelerate functional discovery

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For the activated state, multiple copies of the isolated Bateman domain from our basal structure were docked using Phenix 57 into the central locally refined map and then flexibly fitted into a 10 Å filtered map using Namdinator 59