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This distinguishes it from full-length GH and means that at research-relevant concentrations, the fragment does not produce the insulin resistance, glucose dysregulation, or tissue proliferation associated with GHR-mediated GH signalling — allowing isolated study of the GH lipolytic mechanism without these confounding effects

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If not properly managed, DM may lead to severe late-stage complications that include cerebrovascular, peripheral vascular, and ischemic heart disease, kidney failure, and retinal damage [2,3]