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Oxidative or electrophilic stress disrupts KEAP1-mediated repression, allowing NFE2L2 to accumulate and induce the expression of genes involved in redox homeostasis, iron metabolism, GSH synthesis, and ferroptosis resistance [42-49]
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Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation and cancer: how are they linked
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