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Macrophages are key cells in the inflammatory response, releasing a large number of inflammatory factors

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Megaloblastosis is rarely seen in dogs,75 and some dogs with IGS present with a normal hemogram.76 Although children with this disorder develop macrocytic anemia, the anemia in dogs is usually normocytic and normochromic.72, 87, 88, 89 Thus, megaloblastic anemia does not appear to be as closely associated with cobalamin deficiency in dogs as it is in people