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In trypanosomes, glutathione is largely replaced by the related trypanothione in which two g-Glu-Cys-Gly moieties are linked by peptide bonds through their carboxyl groups to a molecule of spermidine
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They are often studied for their effects on neurotrophic signaling, neurotransmitter systems, synaptic plasticity, stress-response pathways, and other brain-related endpoints in preclinical models and limited human studies
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