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Also, mTORC1 activates the ribosomal protein S6 kinase beta-1 (S6K1) and the eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), promoting the translation of MCL-1 mRNA on ribosomes and the synthesis of Mcl-1 [301]
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These challenges highlight the requirement for an improved delivery system that can overcome the BBB and facilitate targeted delivery to specific pathological brain regions or cell types
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