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DES(1-3) IGF-1 retains native IGF-1's 67-amino acid size and has a plasma half-life of only 20-30 minutes, similar to native IGF-1, whereas IGF-1 LR3's additional bulk and IGFBP evasion extend its half-life to 20-30 hours
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Similar evidence has been found for the formation of transsynaptic complexes between neurexins and other postsynaptic adhesion molecules
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