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12 , 41 , 43 , 48 , 51 , 54 , 55 , 58 , 59 , 61 - 63 , 82 - 85 , 89 , 91 - 93 , 98 , 114 , 116 , 117 ,1 43 - 147 , 149 -1 55 In reality, in particular along with its safe profile, LD-1 not achieved, and no adverse effects in clinical trials, 1 - 13 this evidence suggests easy practical clinical application (Fig