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Show Notes * Notes from intro : In today’s AMA, we take on one of the most requested and most confusing topics we’ve ever covered, peptides Peptides sit at the intersection of biological plausibility, clinical promise, and rampant commercialization They’re often marketed as cutting edge regenerative therapies for everything from muscle repair and longevity to cosmetic enhancements But the reality is that the peptide ecosystem is sprawling, poorly regulated, and filled with claims that range from legitimate to completely ungrounded The goal of this episode is not to promote peptides or dismiss them as a category, but to give you a framework for evaluating them We walk through: What peptides are What questions you should ask before putting any peptide or any drug into your body How to think about: The strength of evidence The safety profile The difference between science and marketing hype Specifically, we’re going to discuss: Why peptides have become such a dominant topic in the wellness and longevity culture The differences between FDA approved peptide therapeutics and “peptides”, which are what most people refer to with quotes in the biohacking world A framework for evaluating any peptide, mechanism, intended effects, safety, dosing, and alternatives Then we’re going to run our framework through a handful of examples in detail SS-31, talk about the background, the biology, and the types of conditions it has been studied for Melanotan-II, receptor activity, common claims, related FDA approved compounds in the same pathway CJC-1295, and talk about growth hormone signaling, why it has been studied in humans, what it’s been studied for, and how dosing is typically approached
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10.3389/fcvm.2022.822079 [DOI] [PMC free article] [PubMed] [Google Scholar] Zilov A