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These peptides act by elevating the expression levels and activity of the SIRT1, Nrf2, HO-1, GSH, SOD, CAT, TAC, IκB-α, Bcl-2, PI3K, and Akt, while lowering the levels of pro-inflammatory and pro-apoptotic markers such as TLR-4, NF-κB, MAPK, IL-1β, IL-6, VCAM, ICAM-1, MPO, MCP-1, GSK-3β, TNF-α, MDA, cytochrome c, caspase-3, Bax, and the Bax/Bcl-2 ratio

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Plast Reconstr Surg 1980