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Adjunctive use of single-carbon folate derivatives, such as folinic acid or l-methylfolate, 61,62,63,64,65 as well as N -acetylcysteine, 66,67,68 which augments GSH levels, has been associated with clinical improvement

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6c), indicating that H 2 O 2 catalyzed by NP4 not only disrupted the redox balance within tumor cells but also diffused outside the cells, leading to more cascading reactions