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Their activity in the brain encompasses the prevention of neuronal fatty acids’ oxidation, a reduction in the damage caused by reactive oxygen and nitrogen species, and an improvement in neurocognition by facilitating de novo protein synthesis in key sites and neurogenesis in the dentate gyrus [133]
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, 8 found lower activities of CuZn-SOD, GPx and CAT in the renal medulla, lower levels of CuZn-SOD, GPx but higher activity of CAT in the renal cortex, whereas Mn-SOD activity was increased in both the cortex and medulla of stroke-prone SHR when compared with age-matched 32-week-old WKY rats
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