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In this study, a heme oxygenase-1 (HO-1) cAMP response element-binding protein (CREB) rat model was used, and the authors found that melatonin mitigates traumatic-brain-injury-induced depression via HO-1/CREB pathway, thus showing melatonin’s neuroprotective properties in traumatic brain injury [49]
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We conducted a systematic review to examine the efficacy and safety of cognitive enhancers for mild cognitive impairment
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