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[7] In the context of schizophrenia, where NMDA receptor hypofunction is a well-established feature, glycine supplementation at doses of 0.4 to 0.8 grams per kilogram of body weight has been tested in clinical trials and found to reduce negative symptoms including social withdrawal and emotional blunting — both of which share mechanistic overlap with anxiety and anhedonia
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The mechanisms, regulations, and functions of histone lysine crotonylation
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