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New in the August 14, 2025, issue of NEJM: ⁣ ⁣ Cagrilintide–Semaglutide for Overweight or Obesity (REDEFINE 1 phase 3a trial)⁣ ⁣ Cagrilintide– Semaglutide for Overweight and Diabetes (REDEFINE 2 phase 3a trial)⁣ ⁣

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Dvorak H

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New and repurposed pharmacological agents, such as mood stabilizers and atypical antipsychotics (especially quetiapine), have been introduced as monotherapies or combined with SSRIs/SNRIs, but these treatments are not recommended as first-line options (Maron and Nutt, 2017)