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The role of integrins in phagocytosis is evolutionarily conserved and can be observed in Caenorhabditis elegans INA-1/PAT-3, which is involved in clearance of apoptotic cells (3), and Drosophila αPS3/βν, which has roles in microbial defense and apoptotic cell removal (4, 5) (Table 1)

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3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems

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