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Mitochondrial Respiration and Hypoxia Protection The 2003 study by Khvatova, Samartzev, Zagoskin, Prudchenko, and Mikhaleva published in Peptides confirmed that DSIP significantly increased ADP-stimulated mitochondrial respiration in rat brain mitochondria under experimental hypoxia conditions — establishing a direct mitochondrial respiratory mechanism for DSIP’s stress-protective potency and linking DSIP biology to the emerging field of mitochondria-targeted neuroprotective peptides