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Also, ASNase consumption of Asp and glutamate could be supplemented by SLC1A3, thus eliminating the inhibitory effect of ASNase and promoting tumor development

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The search included studies published from database inception to April 2026 and focused on original research and relevant reviews concerning secondary lymphedema, lymphatic dysfunction, metabolic dysregulation, immunometabolism, inflammation, fibrosis, adipose remodeling, and metabolism-oriented therapeutic strategies