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It is classified as a triple receptor agonist for its capacity to simultaneously engage the glucose-dependent insulinotropic polypeptide (GIP) receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucagon receptor — a receptor profile that differentiates it from the single- and dual-receptor agonists more commonly evaluated in metabolic pharmacology research
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177 Evaluation of cell permeability by a PAMPA assay revealed that, overall, amide-to-ester substitution had a comparable or superior enhancement effect on cell penetration ability compared to N -methylation
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