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Furthermore, glucocorticoids have been shown to directly promote clock gene expression in both animal 61 and human studies 62

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Piceatannol also inhibited LPS-induced oxidative stress and the resulting inflammatory reaction in brain endothelial cancer cell lines by suppressing the NF-κB and MAPK signaling pathways coupled with down-regulation of adhesion molecules (ICAM-1 and VCAM-1) which in total contributed to the reduction of ROS generation