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Evidence also points to a reflex mechanism (Figures 5B,C) (Tracey, 2009) through which vagal afferent stimulation activates vagal efferent fibers, which in turn trigger splenic T-cells to produce acetylcholine
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In a PD mouse model study, it was found that giving berberine orally increases tyrosine hydroxylase activity in Enterococcus faecalis , leading to higher production of l-DOPA, a dopamine precursor
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