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While mutations of ETC proteins are rarely linked as a direct cause of PD (except for UQCRC1), impaired ETC proteins may not only lead to excessive ROS production, but also cause impeded mitophagy, α-Syn aggregation, and apoptosis in PD pathogenesis

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Drug Dev Res (2009) 70:472–80 10.1002/ddr.20328 [DOI] [Google Scholar] 9.Wright JW, Harding JW