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A similar acid-sensitive linker was utilized to trigger the charge reversal of cis-aconityl functionalized DOX prodrug at acidic pH and subsequently release DOX that was attached to the positively charged PEG-acrylate copolymer though synergetic electrostatic and hydrophobic interactions 149

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Peroxynitrite has cytotoxic effects in human venous endothelial cells and in rat aortic smooth muscle cells