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When human P301L tau was overexpressed in the DRN of mice, depression-like behaviors and hyperactivity were observed without deficits in spatial memory, suggesting that behavioral changes may precede cognitive impairment in AD [45,46] (Figure 6)
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[PubMed] [Google Scholar] Pfaffenbach K.T., Nivala A.M., Reese L., Ellis F., Wang D., Wei Y., Pagliassotti M.J
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