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Secondary injury mechanisms may include intracranial hemorrhage, excitotoxicity, ionic disturbances, decreased cerebral blood flow, edema, inflammation, mitochondrial dysfunction, oxidative stress, nitrosative stress, and (neuronal and glial) cell death by apoptosis
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Age effects and folate status, a modifier of vitamin B 12 metabolism, are also considered (Fedosov et al., 2015)
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