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Concurrently, sustained activation of the sympathetic nervous system and the renin–angiotensin–aldosterone system (RAAS) further compromises cardiovascular adaptive capacity and, through interactions with metabolic and inflammatory disturbances, influences vascular tone regulation, myocardial structural stability, and cardiac electrophysiological balance

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The overall functionality of the CNS is regulated by a balanced interplay between excitatory and inhibitory activity, which is mediated by neurotransmitters glutamate (Glu) and γ-aminobutyric acid (GABA), respectively

Glutathione is a powerful antioxidant that helps to protect the skin from damage caused by free radicals and environmental aggressors