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Two noncanonical c-Myc binding sites (CACATG, E box) are present in the human GCLC promoter at −559/−554 and −500/−495 and together with ARE4, are responsible for H 2 O 2 -induced GCLC promoter activity [120]
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Transition metals such as Fe 2+ also are chelated by melatonin which reduces the formation of the devastatingly toxic ·OH species (162, 163), thought to account for more than 50% of the damage sustained by critical molecules during oxidative stress
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