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Abbreviations ADL Activities of daily living ATP Adenosine triphosphate BBB Blood-brain barrier CAT Catalase CBT Cognitive behavioral therapy CDC Centers for Disease Control and Prevention CFQ Chalder Fatigue Questionnaire ChiCTR Chinese Clinical Trial Register CNS Central nervous system COMPASS Composite Autonomic Symptom Scale CoQ 10 Coenzyme Q 10 DCA Sodium dichloroacetate DHTs Digital health technologies DSQ DePaul Symptom Questionnaire EBV Epstein-Barr virus ETC Electron transport chain FIS Fatigue Impact Scale fMRI Functional magnetic resonance imaging GET Graded exercise therapy GPx Glutathione peroxidase GSH Glutathione H 2 Molecular hydrogen HRV Heart rate variability HSV-1 Herpes simplex virus HUTT Head-Up Tilt Table Test IFN-γ Interferon-gamma IgG Immunoglobulin G IL-1β Interleukin-1β IL-6 Interleukin-6 iNOS Inducible nitric oxide synthase IOM Institute of Medicine IVIG Intravenous immunoglobulin LDN Low-dose naltrexone MAPK Mitogen-activated protein kinase ME/CFS Myalgic Encephalomyelitis/Chronic Fatigue Syndrome MeSH Medical Subject Headings MMSE Mini-Mental State Examination MoCA Montreal Cognitive Assessment NAC N-acetylcysteine NfL Neurofilament light chain NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells NICE National Institute for Health and Care Excellence NK Natural killer NO Nitric oxide PACS Post-acute COVID-19 syndrome PBMCs Peripheral blood mononuclear cells PDH Pyruvate dehydrogenase PDKs Pyruvate dehydrogenase kinases PEM Post-exertional malaise POTS Postural tachycardia syndrome PSQI Pittsburgh Sleep Quality Index RCTs Randomized controlled trials RNA Ribonucleic acid RNS Reactive nitrogen species ROS Reactive oxygen species RWD Real-world data SANRA The Scale for the Assessment of Narrative Review Articles SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 SMN Somatomotor network SOD Superoxide dismutase TCA Tricarboxylic acid TCM Traditional Chinese medicine Th1 T-helper 1 Th2 T-helper 2 Th17 T-helper 17 TLR3 Toll-like receptor 3 TNF-α Tumor necrosis factor-alpha TRPM3 Transient receptor potential cation channel subfamily M member 3 tVNS Transcutaneous vagus nerve stimulation µOR µ-opioid receptors Author contributions JF, JJ and HQC contributed equally to this work

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