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The NF-κB pathway functions as a central pro-survival and pro-inflammatory transcription factor that promotes tumor progression by suppressing tumor suppressors such as phosphatase and tensin homolog (PTEN), thereby indirectly enhancing PI3K/AKT signaling and supporting cancer cell viability

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[PubMed] [Google Scholar] 113.Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB