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Ferroptosis-derived lipid peroxides and DAMPs can activate the TGF-β/Smad3 pathway, creating a feed-forward loop that exacerbates renal fibrosis ( 3.3 Mitochondrial quality control in DN Mitochondrial quality control, including dynamics (fusion/fission) and mitophagy, is essential for maintaining renal cellular integrity (Sun et al., 2024)
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Findings indicate that toxoplasmosis may contribute to host alterations, including the induction of humoral and cellular immune responses, production of various cytokines, and changes in neurotransmitter levels (e.g., serotonin, dopamine, acetylcholine, gamma-aminobutyric acid, and glutamate), as well as the activation of enzymes such as indoleamine 2,3-dioxygenase, which may influence the pathophysiology of ASD