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Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

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Inhibition of the adenosine A2A receptor mitigates excitotoxic injury in Organotypic tissue cultures of the rat Cochlea

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