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David Perlmutter, MD, FACN - World-Renowned Neurologist

Tretinoin is an FDA-approved retinoid with the strongest clinical evidence for photoaging

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Melanocytes from vitiligo patients suffer from excess reactive oxygen species (ROS) produced by defective mitochondria besides a poor endogenous antioxidant system (EAS) ( Vitiligo severity has also been associated with metabolic syndrome (MetS), increasing the prevalence and incidence of MetS or associated disorders such as insulin resistance and hypercholesterolemia (Sharma et al., 2017