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This compound is more stable than O 2 •- , and it can penetrate cell membranes ( • ), singlet oxygen (O 2 1 ), and ozone (O 3 ) with strong bactericidal properties ( 2 •- + H 2 O 2 → OH •- + OH - + O 2 ) and the Fenton reaction (H 2 O 2 + Fe 2+ → Fe 3+ + OH •- + OH - ) with the participation of pro-oxidant ions of transition metals (mostly Fe 2+ /Cu 2+ ) ( In bronchial asthma, ROS act as mediators of asthmatic inflammation and deliver direct pro-asthmatic effects (64)

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In addition to its impact on astrocytic clearance, melatonin may mitigate the burden of Aβ in the brain by promoting lymphatic clearance