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45 As SAM binds, glutamate translocates from the donor site at the entrance of the reaction chamber to the buried acceptor site

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NAC in Obsessive-compulsive Disorder and Autism The antioxidant properties of NAC and its ability to modulate neurotransmitters such as glutamate and dopamine have also led to adjunctive NAC being investigated in obsessive-compulsive disorder (OCD), where excessive glutamatergic activity and altered dopamine signaling are thought to play a role [9]