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These tetramers translocate to the nucleus, where they bind to specific DNA sequences and initiate the transcription of genes associated with apoptosis and cell cycle regulation ( The normal maintenance or post-injury regeneration of rapidly renewing tissues (including the gastrointestinal tract) relies on specific stem cell subpopulations ( 2.2.3 NF-κB NF-κB, a family of highly conserved transcription factors, serves as a pivotal regulator in diverse biological processes, including immune responses, inflammatory reactions, cell survival, proliferation, and oxidative stress modulation ( Numerous investigations have systematically examined the impact of NF-κB inhibition on radiosensitivity across various experimental models ( in vivo , thereby establishing IKKβ as a crucial therapeutic target for the development of radioprotective interventions in the gastrointestinal tract ( Intriguingly, both ATM and DNA-PK exhibit dual regulatory capabilities, facilitating pro-apoptotic responses through P53 stabilization while simultaneously promoting anti-apoptotic responses via NF-κB activation ( 2.2.4 STING STING, a crucial intracellular signaling molecule, serves as a pivotal regulator in the innate immune system

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First case report of primary carnitine deficiency manifested as intellectual disability and autism spectrum disorder